| 1. Total Cognitive Time-Mixed model |
| response between treatment and control untill time 4 |
| Model Information | |
|---|---|
| Data Set | WORK.LSMPLOT |
| Dependent Variable | response |
| Covariance Structure | Unstructured |
| Subject Effect | id |
| Estimation Method | REML |
| Residual Variance Method | None |
| Fixed Effects SE Method | Model-Based |
| Degrees of Freedom Method | Between-Within |
| Dimensions | |
|---|---|
| Covariance Parameters | 10 |
| Columns in X | 19 |
| Columns in Z | 0 |
| Subjects | 74 |
| Max Obs Per Subject | 4 |
| Number of Observations | |
|---|---|
| Number of Observations Read | 407 |
| Number of Observations Used | 265 |
| Number of Observations Not Used | 142 |
| Iteration History | |||
|---|---|---|---|
| Iteration | Evaluations | -2 Res Log Like | Criterion |
| 0 | 1 | 1182.00507246 | |
| 1 | 2 | 951.11531777 | 9.46831482 |
| 2 | 1 | 936.08408120 | 0.04615558 |
| 3 | 1 | 926.43668476 | 0.02073184 |
| 4 | 1 | 920.69767944 | 0.00395448 |
| 5 | 1 | 919.65985177 | 0.00038514 |
| 6 | 1 | 919.56572497 | 0.00000676 |
| 7 | 1 | 919.56417458 | 0.00000000 |
| Convergence criteria met. |
| Estimated R Matrix for id 1025341 | ||||
|---|---|---|---|---|
| Row | Col1 | Col2 | Col3 | Col4 |
| 1 | 1.9623 | 2.7567 | 3.2869 | 3.0172 |
| 2 | 2.7567 | 6.6744 | 7.4870 | 6.8729 |
| 3 | 3.2869 | 7.4870 | 10.0616 | 8.4441 |
| 4 | 3.0172 | 6.8729 | 8.4441 | 8.4107 |
| Estimated R Correlation Matrix for id 1025341 | ||||
|---|---|---|---|---|
| Row | Col1 | Col2 | Col3 | Col4 |
| 1 | 1.0000 | 0.7617 | 0.7397 | 0.7427 |
| 2 | 0.7617 | 1.0000 | 0.9136 | 0.9173 |
| 3 | 0.7397 | 0.9136 | 1.0000 | 0.9179 |
| 4 | 0.7427 | 0.9173 | 0.9179 | 1.0000 |
| Covariance Parameter Estimates | |||||
|---|---|---|---|---|---|
| Cov Parm | Subject | Estimate | Standard Error | Z Value | Pr Z |
| UN(1,1) | id | 1.9623 | 0.3342 | 5.87 | <.0001 |
| UN(2,1) | id | 2.7567 | 0.5462 | 5.05 | <.0001 |
| UN(2,2) | id | 6.6744 | 1.1223 | 5.95 | <.0001 |
| UN(3,1) | id | 3.2869 | 0.6837 | 4.81 | <.0001 |
| UN(3,2) | id | 7.4870 | 1.4060 | 5.33 | <.0001 |
| UN(3,3) | id | 10.0616 | 2.0149 | 4.99 | <.0001 |
| UN(4,1) | id | 3.0172 | 0.6272 | 4.81 | <.0001 |
| UN(4,2) | id | 6.8729 | 1.2480 | 5.51 | <.0001 |
| UN(4,3) | id | 8.4441 | 1.6266 | 5.19 | <.0001 |
| UN(4,4) | id | 8.4107 | 1.5373 | 5.47 | <.0001 |
| Fit Statistics | |
|---|---|
| -2 Res Log Likelihood | 919.6 |
| AIC (smaller is better) | 939.6 |
| AICC (smaller is better) | 940.5 |
| BIC (smaller is better) | 962.6 |
| Null Model Likelihood Ratio Test | ||
|---|---|---|
| DF | Chi-Square | Pr > ChiSq |
| 9 | 262.44 | <.0001 |
| Solution for Fixed Effects | ||||||||
|---|---|---|---|---|---|---|---|---|
| Effect | time | control vs treatment group |
admit type: 1=medical; 2=surgical; 3=other CR |
Estimate | Standard Error | DF | t Value | Pr > |t| |
| Intercept | 1.6369 | 0.5718 | 69 | 2.86 | 0.0056 | |||
| time | 1 | -0.6578 | 0.3650 | 69 | -1.80 | 0.0759 | ||
| time | 2 | -0.4088 | 0.2180 | 69 | -1.88 | 0.0650 | ||
| time | 3 | -0.00530 | 0.2441 | 69 | -0.02 | 0.9827 | ||
| time | 4 | 0 | . | . | . | . | ||
| treatment | Control | -0.8812 | 0.6874 | 69 | -1.28 | 0.2042 | ||
| treatment | Treatment | 0 | . | . | . | . | ||
| concovariate1 | 0.001468 | 0.001828 | 69 | 0.80 | 0.4248 | |||
| concovariate2 | 0.01925 | 0.04320 | 69 | 0.45 | 0.6573 | |||
| catcovariate | 1 | -0.3594 | 0.4632 | 69 | -0.78 | 0.4405 | ||
| catcovariate | 2 | 0 | . | . | . | . | ||
| time*treatment | 1 | Control | 0.3662 | 0.5012 | 69 | 0.73 | 0.4675 | |
| time*treatment | 1 | Treatment | 0 | . | . | . | . | |
| time*treatment | 2 | Control | 0.5787 | 0.2976 | 69 | 1.94 | 0.0559 | |
| time*treatment | 2 | Treatment | 0 | . | . | . | . | |
| time*treatment | 3 | Control | 0.2335 | 0.3340 | 69 | 0.70 | 0.4869 | |
| time*treatment | 3 | Treatment | 0 | . | . | . | . | |
| time*treatment | 4 | Control | 0 | . | . | . | . | |
| time*treatment | 4 | Treatment | 0 | . | . | . | . | |
| Type 3 Tests of Fixed Effects | ||||||
|---|---|---|---|---|---|---|
| Effect | Num DF | Den DF | Chi-Square | F Value | Pr > ChiSq | Pr > F |
| time | 3 | 69 | 4.43 | 1.48 | 0.2187 | 0.2286 |
| treatment | 1 | 69 | 1.10 | 1.10 | 0.2935 | 0.2972 |
| concovariate1 | 1 | 69 | 0.64 | 0.64 | 0.4221 | 0.4248 |
| concovariate2 | 1 | 69 | 0.20 | 0.20 | 0.6559 | 0.6573 |
| catcovariate | 1 | 69 | 0.60 | 0.60 | 0.4378 | 0.4405 |
| time*treatment | 3 | 69 | 4.02 | 1.34 | 0.2594 | 0.2686 |
| Least Squares Means | |||||||
|---|---|---|---|---|---|---|---|
| Effect | time | control vs treatment group |
Estimate | Standard Error | DF | t Value | Pr > |t| |
| time | 1 | 0.7284 | 0.2393 | 69 | 3.04 | 0.0033 | |
| time | 2 | 1.0837 | 0.3481 | 69 | 3.11 | 0.0027 | |
| time | 3 | 1.3146 | 0.4153 | 69 | 3.17 | 0.0023 | |
| time | 4 | 1.2031 | 0.3847 | 69 | 3.13 | 0.0026 | |
| treatment | Control | 0.7891 | 0.4255 | 69 | 1.85 | 0.0679 | |
| treatment | Treatment | 1.3757 | 0.4372 | 69 | 3.15 | 0.0024 | |
| time*treatment | 1 | Control | 0.4709 | 0.2908 | 69 | 1.62 | 0.1100 |
| time*treatment | 1 | Treatment | 0.9859 | 0.2888 | 69 | 3.41 | 0.0011 |
| time*treatment | 2 | Control | 0.9324 | 0.4532 | 69 | 2.06 | 0.0434 |
| time*treatment | 2 | Treatment | 1.2349 | 0.4670 | 69 | 2.64 | 0.0101 |
| time*treatment | 3 | Control | 0.9907 | 0.5494 | 69 | 1.80 | 0.0757 |
| time*treatment | 3 | Treatment | 1.6384 | 0.5732 | 69 | 2.86 | 0.0056 |
| time*treatment | 4 | Control | 0.7625 | 0.5061 | 69 | 1.51 | 0.1365 |
| time*treatment | 4 | Treatment | 1.6437 | 0.5254 | 69 | 3.13 | 0.0026 |
| Differences of Least Squares Means | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Effect | time | control vs treatment group |
_time | control vs treatment group |
Estimate | Standard Error | DF | t Value | Pr > |t| |
| time | 1 | 2 | -0.3553 | 0.2057 | 69 | -1.73 | 0.0887 | ||
| time | 1 | 3 | -0.5862 | 0.2829 | 69 | -2.07 | 0.0420 | ||
| time | 1 | 4 | -0.4747 | 0.2506 | 69 | -1.89 | 0.0624 | ||
| time | 2 | 3 | -0.2309 | 0.1733 | 69 | -1.33 | 0.1872 | ||
| time | 2 | 4 | -0.1195 | 0.1488 | 69 | -0.80 | 0.4249 | ||
| time | 3 | 4 | 0.1114 | 0.1670 | 69 | 0.67 | 0.5068 | ||
| treatment | Control | Treatment | -0.5866 | 0.5584 | 69 | -1.05 | 0.2972 | ||
| time*treatment | 1 | Control | 1 | Treatment | -0.5150 | 0.3270 | 69 | -1.58 | 0.1198 |
| time*treatment | 1 | Control | 2 | Control | -0.4615 | 0.2830 | 69 | -1.63 | 0.1075 |
| time*treatment | 1 | Control | 2 | Treatment | -0.7640 | 0.4915 | 69 | -1.55 | 0.1246 |
| time*treatment | 1 | Control | 3 | Control | -0.5198 | 0.3865 | 69 | -1.34 | 0.1831 |
| time*treatment | 1 | Control | 3 | Treatment | -1.1675 | 0.5945 | 69 | -1.96 | 0.0536 |
| time*treatment | 1 | Control | 4 | Control | -0.2916 | 0.3435 | 69 | -0.85 | 0.3988 |
| time*treatment | 1 | Control | 4 | Treatment | -1.1728 | 0.5482 | 69 | -2.14 | 0.0359 |
| time*treatment | 1 | Treatment | 2 | Control | 0.05349 | 0.4772 | 69 | 0.11 | 0.9111 |
| time*treatment | 1 | Treatment | 2 | Treatment | -0.2490 | 0.2987 | 69 | -0.83 | 0.4075 |
| time*treatment | 1 | Treatment | 3 | Control | -0.00481 | 0.5695 | 69 | -0.01 | 0.9933 |
| time*treatment | 1 | Treatment | 3 | Treatment | -0.6525 | 0.4132 | 69 | -1.58 | 0.1189 |
| time*treatment | 1 | Treatment | 4 | Control | 0.2234 | 0.5282 | 69 | 0.42 | 0.6736 |
| time*treatment | 1 | Treatment | 4 | Treatment | -0.6578 | 0.3650 | 69 | -1.80 | 0.0759 |
| time*treatment | 2 | Control | 2 | Treatment | -0.3025 | 0.6020 | 69 | -0.50 | 0.6169 |
| time*treatment | 2 | Control | 3 | Control | -0.05829 | 0.2342 | 69 | -0.25 | 0.8042 |
| time*treatment | 2 | Control | 3 | Treatment | -0.7060 | 0.6887 | 69 | -1.03 | 0.3089 |
| time*treatment | 2 | Control | 4 | Control | 0.1699 | 0.2027 | 69 | 0.84 | 0.4047 |
| time*treatment | 2 | Control | 4 | Treatment | -0.7113 | 0.6491 | 69 | -1.10 | 0.2770 |
| time*treatment | 2 | Treatment | 3 | Control | 0.2442 | 0.6775 | 69 | 0.36 | 0.7196 |
| time*treatment | 2 | Treatment | 3 | Treatment | -0.4035 | 0.2556 | 69 | -1.58 | 0.1190 |
| time*treatment | 2 | Treatment | 4 | Control | 0.4724 | 0.6431 | 69 | 0.73 | 0.4651 |
| time*treatment | 2 | Treatment | 4 | Treatment | -0.4088 | 0.2180 | 69 | -1.88 | 0.0650 |
| time*treatment | 3 | Control | 3 | Treatment | -0.6477 | 0.7555 | 69 | -0.86 | 0.3943 |
| time*treatment | 3 | Control | 4 | Control | 0.2282 | 0.2280 | 69 | 1.00 | 0.3203 |
| time*treatment | 3 | Control | 4 | Treatment | -0.6530 | 0.7197 | 69 | -0.91 | 0.3674 |
| time*treatment | 3 | Treatment | 4 | Control | 0.8759 | 0.7249 | 69 | 1.21 | 0.2311 |
| time*treatment | 3 | Treatment | 4 | Treatment | -0.00530 | 0.2441 | 69 | -0.02 | 0.9827 |
| time*treatment | 4 | Control | 4 | Treatment | -0.8812 | 0.6874 | 69 | -1.28 | 0.2042 |