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Title: Mean (and Mean Difference) of ALT (Alanine Aminotransferase) by Treatment : Profile Over Time

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Title Mean (and Mean Difference) of ALT (Alanine Aminotransferase) by Treatment : Profile Over Time
Graph_Subgroup Labs Liver
Labs_Liver_Clinical_Question

Description This is a plot of the mean of one laboratory parameter, alanine aminotransferase (ALT) by treatment group over the time course of a trial. The x-axis represents the study week and it is important that the axis scale be uniformly separated (for instance in this graphic each tick mark space represents 2 weeks). The y-axis represents the mean value in the appropriate units for the lab parameter. Below the graph are both a legend indicating the treatment groups depicted on the graph and a legend indicating the at risk subject population by treatment group at each specific visit. Note that due to the uniform axis separation, and the visit schedule of the study, there may be blanks if there is no data for a specific visit. It is important to consider that if a color graph is not presented, the line styles will allow for distinction between treatment groups.
Note that there are 4 versions of the graph represented. Figure 1 and Figure 2 are very similar and in fact, differ only in the number of treatments. Figure 3 plots the difference of the 2 active treatments in Figure 2 relative to placebo. This allows for an easier comparison visually and offers more effective confidence intervals (confidence intervals non including zero indicate significance). Figure 4 combines Figures 2&3 by plotting the Mean above the Mean Difference.

Note: Due to the complexity of the code, some attributes that are recommended have not yet been incorporated. The following list of attributes are suggestive enhancements:
• If error bars are consistently symmetric, then the removal of the lower half of the error bars would help to clarify the plot area.
• The addition of a banded section or additional reference lines indicating the normal ranges (if applicable) is desirable. Note that on Figure 1, a banded region has been included as an example. However, the banded region in Figure 1 is only an example and does not accurately reflect the normal reference ranges for ALT.
Contributor/Email Robert Gordon (rgordon2@its.jnj.com)
Additional_Contributor_Info Output and Code created by the SAS Institute on the following website:
http://support.sas.com/sassamples/graphgallery/Health_and_Life_Sciences.html
Background The original graphic which was the inspiration for this specific figure was created by the SAS Institute at the following website:
http://support.sas.com/sassamples/graphgallery/Health_and_Life_Sciences.html
The code for the ‘Median of Lipid Profile over Time’ graphic on the above website was adapted for use with the CDISC ADLBC (lab) dataset available on the CTSPedia Statistical Graphics Page.
Keywords Line plot, Liver Function Test, ALT, Mean
References http://support.sas.com/sassamples/graphgallery/Health_and_Life_Sciences.html
Datasets

CDISC_Data ADLBC
Data_Format

CLASSIFICATIONS

Graph_Type Line Plot
Variable_Relationship Continuous versus Continuous
Data_Types Continuous
Special_Considerations The code would need to be customized in order to allow for additional treatment groups. Additionally, the above code creates an ‘at risk’ dataset. Optimally, the at risk numbers of subjects for each visit would be pulled directly in from a disposition dataset.
Code_Available Yes
Software Program SAS
Software SAS V9.2
R-Code - Attachment

R-Code

SAS-Code - Attachment Gordon - Mean Lab Provfle - SAS - Doc
Stata-Code - Attachment

Stata-Code

Other Code - Attachment

Other Code

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Reference Image Fig1_MeanALT_200.jpg
Topic revision: r16 - 18 Jun 2012 - 11:32:41 - MaryBanach
 

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