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Title: AUCGEE

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Type of Tool SAS Macro
Title A U C G E E
Programmer/Email YinglinXia, ArthurWatts
Contributing Site Rochester
Description This macro is designed to model the area under the curve (AUC) computed from multiple samples within each individual in a longitudinal data setting and compare the differences between two such AUCs while adjusting for covariatesí effects.

The AUCGEE macro first computes the area under the curve (AUC) using the trapezoid formula, then uses the generalized equations estimating (GEE) approach implemented in SAS PROC GENMOD procedure to model the AUC difference between two treatment groups, adjusting for covariatesí effects. The least square means (covariate-adjusted group means) are also obtained from the GEE model and plotted along with the GEE output. The user can specify the output in a HTML, RTF or listing format.

The macro assumes that the data has a longitudinal format with several visits (identified by the rows) and within each visit, the multiple outcomes (identified by the columns) represent the multiple samples such as cortisol levels at different time points collected from the same subject.


Example Example Code
Classification Graph Type

References

Datasets Other
Data Rochester_AUCGEE_Download Dataset

Software Program SAS
Software SAS
Macro Parameters The macro parameters are as follows:

DSname =name of SAS data set
DVar =name of response variable visit =name of visit variable
group =name of treatment groups, which are dichotomized as treatment and control
Endvisit =name of indicator of end visit point
Ntimepoint =number of sample time points
Nvalues =number of samples
CovCat =name of categorical covariates
CovCon =name of continuous covariates
id =name of the variable for subject id
type =type of working correlation matrix
format =output format
title =name of title
R-Code - Attachment

R-Code

SAS-Code - Attachment AUCGEE Main Macro
SAS-Code

Stata-Code - Attachment

Stata-Code

Other Code - Attachment

Other Code

Called Data Manipulation

Called Tool/Utility

Called Checking Macro

Called Other

Creation-Date

Revision-Date June 03, 2010
Example Code SAS Example Code
Example Output SAS Example Output
SAS Examples

SAS_Example_Code Rochester_AUCGEE_SAS Example Code
SAS_Example_Output Rochester_AUCGEE_SAS Output as MHT
Rochester_AUCGEE_SAS Example Output
R Examples

R_Example_Code

R_Example_Output

Stats Examples

Special Features

Special Features Attached

Special Features Text

Notes1-Legend Section with calls to needed macros
Notes1

Notes2-Legend Macro call with fully specified parameters
Notes2

Notes3-Legend Section with definitions of global macro parameters
Notes3

Notes4-Legend Section with definitions of local macro variables
Notes4

See Also

Checklists

Stat Tools Disclaimer This SAS macro is developed by Yinglin Xia and Art Watts, along with other members in the Department of Biostatistics and Computational Biology at the University of Rochester under the auspice of the CTSI BERD with the intent to facilitate data analyses and reporting in clinical and related research. It is copyrighted by Yinglin Xia and Art Watts, June, 2010 and distributed for free public access.
Discliamer The views expressed within CTSpedia are those of the author and must not be taken to represent policy or guidance on the behalf of any organization or institution with which the author is affiliated.
Permission Permission is hereby granted, free of charge, to any person obtaining a copy of this software and associated documentation files (the "Software"), to deal in the Software without restriction, including without limitation the rights to use, copy, modify, merge, publish, distribute, sublicense, and/or sell copies of the Software, and to permit persons to whom the Software is furnished to do so, subject to the following conditions:

The above copyright notice and this permission notice shall be included in all copies or substantial portions of the Software.

THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF ERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE AUTHORS OR COPYRIGHT OLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM, OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE SOFTWARE.
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Topic revision: r25 - 21 Jun 2012 - 13:38:15 - MaryBanach
 

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