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Title Impacting Clinical Care
Year 2010
Contributor/Contact Frank Harrell
CTSA Vanderbilt
Success Topic Methods papers
Description of Success On the methodology development side, the presentation below which is currently under review was due to a BERD member's folllowing up on the data analysis in a deeper way: Zhou XK, Liu F, Dannenberg, AJ (2010), A Bayesian Model Averaging Approach to Differentially Expressed Gene Detection in Observational Microarray Studies, International Biometric Society-Eastern North American Region (ENAR) 2010 Spring Meeting, New Orleans. On the clinical research side, multiple BERD members contribution resulting in multiple publications impacted change in clinical care. One paper referred below in particular, finding 1) that the risk of complications increases in bilateral knee replacement procedures, especially in patients with certain baseline risk factors and 2) that staging two knee replacements several days apart during the same hospital visit increases the risk of surgical complications, prompted a committee of hospital physicians, led by the Physician in Chief, to update existing guidelines about who should be excluded from bilateral and staged knee replacements during one hospitalization due to risk factors. Stavros G. Memtsoudis. Yan Ma, Alejandro González Della Valle, Mazumdar M, Licia K. Gaber-Baylis, C. Ronald MacKenzie, Thomas P. Sculco: Perioperative outcomes after unilateral and bilateral total knee arthroplasty. Anesthesiology, 111(6):1206-16, 2009
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Topic revision: r4 - 10 Apr 2012 - 15:39:28 - MaryBanach

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