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Title Methodological Grants at UT Southwestern
Year 2010
Contributor/Contact Chul Ahn
CTSA UT Southwestern
Success Topic Methods/core grants
Description of Success Four biostatisticians (Drs. Chao Xing, Guanghua Xiao, Yang Xie and Rafia Bhore) received CTSA pilot methodology grants during the current CTSA funding period. These pilot grants generated much needed preliminary data that enabled biostatistics faculty to obtain extramural grants for the development of innovative statistical methods from American Hear Association (Dr. Xing), NSF and NIH (Dr. Xiao), and NIH (Dr. Xiao).

Dr. Xie received an NCI R01 methodology grant on the development of comprehensive prediction models for adjuvant chemotherapy response.

Dr. Xing worked on the following two questions through a CTSA pilot award. First, given certain cost, how many individuals should we genotype in order to achieve maximal power? Second, consider that the commercial arrays designed for GWAS mainly capture common variants, how can we maximize power to detect association for low-frequency variants? These two questions interweave with each other because the statistical power of association tests depend on allele frequency. The CTSA pilot award led to a new statistical approach to detect association for low-frequency variants, discovery of a new gene associated with plasma glucose levels, and it evolved into the award of American Heart Association grant.

Dr. Xiao received a CTSA pilot award titled “Adaptive prediction for genomic or proteomic signatures based clinical trials”, which led to NSF grant titled “Bayesian Hierarchical Methods for Modeling Chromosomal Spatial Correlation”, and NIH R21 grant award titled “Secondary data analyses for substance abuse research”.

Dr. Bhore received a CTSA supplementary award for BERD evaluation metrics.
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Open to Public Yes
BERD Watch No
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Topic revision: r5 - 29 Aug 2011 - 11:29:19 - MaryBanach

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