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Title Preliminary Report on Cox-2 Haplotype and Colorectal Cancer Differentiation
Year 2011
Contributor/Contact John Kwagyan (email: jkwagyan@howard.edu)
CTSA Georgetown-Howard
Success Topic Collaboration, Manuscripts, Methods papers
Description of Success Single nucleotide polymorphisms (SNPs) in the promoter and untranslated region of COX-2, an inducible enzyme responsible for the synthesis of prostaglandins, have been reported to modulate the risk for many human cancers. BERD statistician, (John Kwagyan ,2012), from Georgetown-Howard CTSA in collaboration with basic scientist performed comprehensive linkage disequilibrium (LD) and haplotype analyses of 13 SNPs of the COX-2 gene and examined its susceptibility to adenoma development in 72 African American cases and142 controls. To avoid ramification of multicollinearity, because SNPs that are in LD are highly correlated and serve as good surrogates for each other, we defined and identified 4 distinct sets of “family of SNPs” that mutually exhibit strong evidence of recombination with one another within the family. Several linear models, each corresponding to a “family of SNPs” that mutually exhibit strong evidence of recombination with one another within the set were fitted and the final (most parsimonious) model was selected based on the Akaike’s Information Criterion (AIC). Results revealed significant variation in LD patterns with consequence for adenoma development. This preliminary report, to appear in Clinical & Translational Science, is one of limited studies that have thoroughly examined linkage disequilibrium and haplotype patterns in a moderately large candidate SNPs and its association to colorectal adenoma development and the only one in an African American population. Kwagyan J, Apprey V, Ashktorab, HA. Clinical & Translational Science. 2012 (in press).
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Topic revision: r1 - 04 Dec 2011 - 20:00:58 - JohnKwagyan

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